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  • Guan, W., R. Guyot, J. Samarut, F. Flamant, J. Wong, and K. C. Gauthier. 2017. Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin. Proc Natl Acad Sci U S A 114:8229-8234.
  • Flamant, F., K. Gauthier, and S. Richard. 2017. Genetic Investigation of Thyroid Hormone Receptor Function in the Developing and Adult Brain. Curr Top Dev Biol 125:303-335.
  • Flamant, F., S. Y. Cheng, A. N. Hollenberg, L. C. Moeller, J. Samarut, F. E. Wondisford, P. M. Yen, and S. Refetoff. 2017. Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature. Endocrinology 158:2052-2057.
  • Richard, S., N. Aguilera, M. Thevenet, O. Dkhissi-Benyahya, and F. Flamant. 2017. Neuronal expression of a thyroid hormone receptor alpha mutation alters mouse behaviour. Behav Brain Res 321:18-27.



  • Arbogast, P., F. Flamant, P. Godement, M. Glosmann, and L. Peichl. 2016. Thyroid Hormone Signaling in the Mouse Retina. PLoS One 11:e0168003.
  • Finan, B., C. Clemmensen, Z. Zhu, K. Stemmer, K. Gauthier, et al. 2016. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. Cell 167:843-857 e814.
  • Flamant, F. 2016. Futures Challenges in Thyroid Hormone Signaling Research. Front Endocrinol (Lausanne) 7:58.
  • Markossian, S., and F. Flamant. 2016. CRISPR/Cas9: a breakthrough in generating mouse models for endocrinologists. J Mol Endocrinol 57:R81-92.


  • Vlaeminck-Guillem V, Espiard S, Flamant F, Wémeau JL. 2015. TRα receptor mutations extend the spectrum of syndromes of reduced sensitivity to thyroid hormone. Presse Med 44:1103-12.
  • Flamant, F., N. Koibuchi, and J. Bernal. 2015. Editorial: "Thyroid Hormone in Brain and Brain Cells". Front Endocrinol (Lausanne) 6:99.
  • Ozmadenci, D., O. Feraud, S. Markossian, E. Kress, B. Ducarouge, B. Gibert, J. Ge, I. Durand, N. Gadot, M. Plateroti, A. Bennaceur-Griscelli, J. Y. Scoazec, J. Gil, H. Deng, A. Bernet, P. Mehlen, and F. Lavial. 2015. Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance. Nat Commun 6:7398.
  • Espiard, S., F. Savagner, F. Flamant, V. Vlaeminck-Guillem, R. Guyot, M. Munier, M. d'Herbomez, W. Bourguet, G. Pinto, C. Rose, P. Rodien, and J. L. Wemeau. 2015. A novel mutation in THRA gene associated with an atypical phenotype of resistance to thyroid hormone. J Clin Endocrinol Metab. 100:2841-2848.
  • Chatonnet, F., F. Flamant, and B. Morte. 2015. A temporary compendium of thyroid hormone target genes in brain. Biochim Biophys Acta 1849:122-129.


  • Chatonnet, F., G. Livera, B. Fumel, E. S. Fouch, and F. Flamant. 2014. Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells. Mol Reprod Dev 81:1159-1166.
  • Guyot, R., F. Chatonnet, B. Gillet, S. Hughes, and F. Flamant. 2014. Toxicogenomic analys-is of the ability of brominated flame retardants TBBPA and BDE-209 to disrupt thyroid hormone signaling in neural cells. Toxicology 325C:125-132.
  • Gauthier, K., and F. Flamant. 2014. Nongenomic, TRbeta-Dependent, Thyroid Hormone Response Gets Genetic Support. Endocrinology 155:3206-3209.
  • Desjardin, C., C. Charles, C. Benoist-Lasselin, J. Riviere, M. Gilles, O. Chassande, C. Morgenthaler, D. Laloe, J. Lecardonnel, F. Flamant, L. Legeai-Mallet, and L. Schibler. 2014. Chondrocytes play a major role in the stimulation of bone growth by thyroid hormone. Endocrinology 155(8):3123-35.
  • Chatonnet, F., F. Flamant, and B. Morte. 2014. A temporary compendium of thyroid hormone target genes in brain. Biochim Biophys Acta.
  • Flamant, F., J. Y. Borg, B. Lenormand, and V. Le Cam-Duchez. 2014. [Comparison between the centrifugation on MPA C10 (Roche Diagnostics) and the centrifugation according recommendations of GEHT (Groupe d'etude de l'hemostase et de la thrombose) for the daily hemostasis assays]. Ann Biol Clin (Paris) 72:231-235.
  • Picou, F., T. Fauquier, F. Chatonnet, S. Richard, and F. Flamant. 2014a. Deciphering direct and indirect influence of thyroid hormone with mouse genetics. Mol Endocrinol 28:429-441.
  • Fauquier, T., F. Chatonnet, F. Picou, S. Richard, N. Fossat, N. Aguilera, T. Lamonerie, and F. Flamant. 2014. Purkinje cells and Bergmann glia are primary targets of the TRalpha1 thyroid hormone receptor during mouse cerebellum postnatal development. Development 141:166-175.
  • Selmi-Ruby, S., L. Bouazza, M. J. Obregon, A. Conscience, F. Flamant, J. Samarut, F. Borson-Chazot, and B. Rousset. 2014. The Targeted Inactivation of TRbeta Gene in Thyroid Follicular Cells Suggests a New Mechanism of Regulation of Thyroid Hormone Production. Endocrinology 155:635-646.
  • Dettling, J., C. Franz, U. Zimmermann, S. C. Lee, A. Bress, N. Brandt, R. Feil, M. Pfister, J. Engel, F. Flamant, L. Ruttiger, and M. Knipper. 2014. Autonomous functions of murine thyroid hormone receptor TRalpha and TRbeta in cochlear hair cells. Mol Cell Endocrinol 382:26-37.
  • Flamant, F., and K. Gauthier. 2013. "Thyroid hormone receptors: The challenge of elucidating isotype-specific functions and cell-specific response". Biochim Biophys Acta 1830:3900-3907.
  • Chatonnet F., R. Guyot, G. Benoît and F. Flamant. 2013. "Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells." Proc Natl Acad Sci U S A 110(8): E766–75.
  • Avci, H. X., F. Flamant, and I. Dusart. 2013. "Thyroid hormone T3 triggers the developmental loss of axonal regenerative capacity". Med Sci (Paris) 29:245-247.
  • Avci, H.X., C. Lebrun, R. Wehrle, M. Doulazmi, F. Chatonnet, M.P. Morel, M. Ema, G. Vodjdani, C. Sotelo, F. Flamant, and I. Dusart. 2012. "Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor alpha1 and kruppel-like factor 9 in Purkinje cells." Proc Natl Acad Sci U S A 109(35):14206-11.
  • Flamant, F., and K. Gauthier. 2012. "Thyroid hormone receptors: The challenge of elucidating isotype-specific functions and cell-specific response." Biochim Biophys Acta. (in press)
  • Chatonnet, F., R. Guyot, F. Picou, M. Bondesson, and F. Flamant. 2012. "Genome-wide search reveals the existence of a limited number of thyroid hormone receptor alpha target genes in cerebellar neurons." PLoS One 7 (5): e30703.
  • Fumel, B., M.J. Guerquin, G. Livera, C. Staub, M. Magistrini, C. Gauthier, F. Flamant, F. Guillou, and S. Fouchecourt. 2012. "Thyroid hormone limits postnatal sertoli cell proliferation in vivo by activation of its alpha1 isoform receptor (TRalpha1) present in these cells and by regulation of Cdk4/JunD/c-myc mRNA levels in mice." Biol Reprod 87 (1): 16.
  • Dusart, I., and F. Flamant. 2012. "Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal weeks: a metamorphosis?" Front Neuroanat 6: 11.
  • Picou, F., T. Fauquier, F. Chatonnet, and F. Flamant. 2012. "A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation." Mol Endocrinol 26 (4): 608-618.
  • Chatonnet, F., F. Picou , T. Fauquier, and F. Flamant. 2011. "Thyroid hormone action in cerebellum and cerebral cortex development." J Thyroid Res 2011:145762.
  • Goumidi, L., F. Flamant, C. Lendon, D. Galimberti, F. Pasquier, E. Scarpini, D. Hannequin, D. Campion, P. Amouyel, J.C. Lambert, and A. Meirhaeghe. 2011. "Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease." Neurobiol Aging 32 (4): 624-630.
  • Fossat, N., V. Jones, P.L. Khoo, D. Bogani, A. Hardy, K. Steiner, M. Mukhopadhyay, H. Westphal, P.M. Nolan, R. Arkell, and P.P. Tam. 2011. "Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo." Development 138 (4): 667-676.
  • Fauquier, T., E. Romero, F. Picou, F. Chatonnet, X.N. Nguyen, L. Quignodon, and F. Flamant. 2011. "Severe impairment of cerebellum development in mice expressing a dominant-negative mutation inactivating thyroid hormone receptor alpha1 isoform." Dev Biol, in press.
  • Chatonnet, F., T. Fauquier, F. Picou, R. Guyot, and F. Flamant. 2011. "[Thyroid hormone and cerebellum development: Direct and indirect effects?]." Ann Endocrinol (Paris) 72 (2): 99-102.



  • Hernandez, A., L. Quignodon, M.E. Martinez, F. Flamant, and D.L. St Germain. 2010. "Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levels." Endocrinology 151 (11): 5550-5558.
  • Flamant, F., and L. Quignodon. 2010. "Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo." Heart Fail Rev 15 (2): 117-120.
  • Beby, F., M. Housset, N. Fossat, C. Le Greneur, F. Flamant, P. Godement, and T. Lamonerie. 2010. "Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration." PLoS One 5 (7): e11673.
  • Winter, H., L. Ruttiger, M. Muller, S. Kuhn, N. Brandt, U. Zimmermann, B. Hirt, A. Bress, M. Sausbier, A. Conscience, F. Flamant, Y. Tian, J. Zuo, M. Pfister, P. Ruth, H. Lowenheim, J. Samarut, J. Engel, and M. Knipper. 2009. "Deafness in TRbeta mutants is caused by malformation of the tectorial membrane." J Neurosci 29 (8): 2581-2587.
  • Vujovic, M., K. Nordstrom, K. Gauthier, F. Flamant, T.J. Visser, B. Vennstrom, and J. Mittag. 2009. "Interference of a mutant thyroid hormone receptor alpha1 with hepatic glucose metabolism." Endocrinology 150 (6): 2940-2947.
  • Nishio, S., T. Kakizawa, G. Chatelain, G. Triqueneaux, F. Brunet, J. Rambaud, T. Lamonerie, and V. Laudet. 2008. "OTX5 regulates pineal expression of the zebrafish REV-ERB alpha through a new DNA binding site." Mol Endocrinol 22 (1): 23-32.
  • Flamant, F., and L. Quignodon. 2008. "[Thyroid hormone and its receptors: have mouse genetics clarified the situation?]." J Soc Biol 202 (2): 67-71.
  • Bassett, J.H., A.J. Williams, E. Murphy, A. Boyde, P.G. Howell, R. Swinhoe, M. Archanco, F. Flamant, J. Samarut, S. Costagliola, G. Vassart, R.E. Weiss, S. Refetoff, and G.R. Williams. 2008. "A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism." Mol Endocrinol 22 (2): 501-512.
  • Quignodon, L., S. Vincent, H. Winter, J. Samarut, and F. Flamant. 2007. "A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism." Mol Endocrinol 21 (10): 2350-2360.
  • Quignodon, L., C. Grijota-Martinez, E. Compe, R. Guyot, N. Allioli, D. Laperriere, R. Walker, P. Meltzer, S. Mader, J. Samarut, and F. Flamant. 2007. "A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum." J Mol Endocrinol 39 (1): 17-28.
  • Fossat, N., C. Le Greneur, F. Beby, S. Vincent, P. Godement, G. Chatelain, and T. Lamonerie. 2007. "A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors." BMC Dev Biol 7: 122.
  • Flamant, F., K. Gauthier, and J. Samarut. 2007. "Thyroid hormones signaling is getting more complex: STORMs are coming." Mol Endocrinol 21 (2): 321-333.
  • Dkhissi-Benyahya, O., C. Gronfier, W. De Vanssay, F. Flamant, and H.M. Cooper. 2007. "Modeling the role of mid-wavelength cones in circadian responses to light." Neuron 53 (5): 677-687.
  • Crozet, C., S. Lezmi, F. Flamant, J. Samarut, T. Baron, and A. Bencsik. 2007. "Peripheral circulation of the prion infectious agent in transgenic mice expressing the ovine prion protein gene in neurons only." J Infect Dis 195 (7): 997-1006.
  • Fossat, N., G. Chatelain, G. Brun, and T. Lamonerie. 2006. "Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout." EMBO Rep 7 (8): 824-830.
  • Flamant, F., J.D. Baxter, D. Forrest, S. Refetoff, H. Samuels, T.S. Scanlan, B. Vennstrom, and J. Samarut. 2006. "International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors." Pharmacol Rev 58 (4): 705-711.
  • Chatelain, G., N. Fossat, G. Brun, and T. Lamonerie. 2006. "Molecular dissection reveals decreased activity and not dominant negative effect in human OTX2 mutants." J Mol Med 84 (7): 604-615.



  • Fossat, N., V. Courtois, G. Chatelain, G. Brun, and T. Lamonerie. 2005. "Alternative usage of Otx2 promoters during mouse development." Dev Dyn 233 (1): 154-160.
  • Quignodon, L., C. Legrand, N. Allioli, A. Guadano-Ferraz, J. Bernal, J. Samarut, and F. Flamant. 2004. "Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development." J Mol Endocrinol 33 (2): 467-476.
  • Mai, W., M.F. Janier, N. Allioli, L. Quignodon, T. Chuzel, F. Flamant, and J. Samarut. 2004. "Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life." Proc Natl Acad Sci U S A 101 (28): 10332-10337.
  • Dupre, S.M., H. Guissouma, F. Flamant, I. Seugnet, T.S. Scanlan, J.D. Baxter, J. Samarut, B.A. Demeneix, and N. Becker. 2004. "Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone." Endocrinology 145 (5): 2337-2345.
  • Bonnafe, E., M. Touka, A. AitLounis, D. Baas, E. Barras, C. Ucla, A. Moreau, F. Flamant, R. Dubruille, P. Couble, J. Collignon, B. Durand, and W. Reith. 2004. "The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification." Mol Cell Biol 24 (10): 4417-4427.
  • Yen, P.M., X. Feng, F. Flamant, Y. Chen, R.L. Walker, R.E. Weiss, O. Chassande, J. Samarut, S. Refetoff, and P.S. Meltzer. 2003. "Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice." EMBO Rep 4 (6): 581-587.
  • Poguet, A.L., C. Legrand, X. Feng, P.M. Yen, P. Meltzer, J. Samarut, and F. Flamant. 2003. "Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum." Dev Biol 254 (2): 188-199.
  • Flamant, F., and J. Samarut. 2003. "Thyroid hormone receptors: lessons from knockout and knock-in mutant mice." Trends Endocrinol Metab 14 (2): 85-90.
  • Courtois, V., G. Chatelain, Z.Y. Han, N. Le Novere, G. Brun, and T. Lamonerie. 2003. "New Otx2 mRNA isoforms expressed in the mouse brain." J Neurochem 84 (4): 840-853.
  • Gauthier, K., D. Aubert, O. Chassande, F. Flamant, and J. Samarut. 2002. "Null mutant mice for thyroid hormone receptors." Methods Mol Biol 202: 13-29.
  • Flamant, F., A.L. Poguet, M. Plateroti, O. Chassande, K. Gauthier, N. Streichenberger, A. Mansouri, and J. Samarut. 2002. "Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene." Mol Endocrinol 16 (1): 24-32.
  • Baas, D., C. Legrand, J. Samarut, and F. Flamant. 2002. "Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors." Proc Natl Acad Sci U S A 99 (5): 2907-2911.
  • Crozet, C., F. Flamant, A. Bencsik, D. Aubert, J. Samarut, and T. Baron. 2001. "Efficient transmission of two different sheep scrapie isolates in transgenic mice expressing the ovine PrP gene." J Virol 75 (11): 5328-5334.
  • Crozet, C., A. Bencsik, F. Flamant, S. Lezmi, J. Samarut, and T. Baron. 2001. "Florid plaques in ovine PrP transgenic mice infected with an experimental ovine BSE." EMBO Rep 2 (10): 952-956.