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Research articles





  • Storelli, G., and F. Leulier. 2016. [Juvenile growth, chronic undernutrition and microbiota: the growth-promoting effect of specific Lactobacilli strains is conserved from fruit flies to mice]. Med Sci (Paris) 32:925-929.
  • Martino, M. E., J. R. Bayjanov, B. E. Caffrey, M. Wels, P. Joncour, S. Hughes, B. Gillet, M. Kleerebezem, S. A. van Hijum, and F. Leulier. 2016. Nomadic lifestyle of Lactobacillus plantarum revealed by comparative genomics of 54 strains isolated from different habitats. Environ Microbiol 18:4974-4989.
  • Strigini, M., and F. Leulier. 2016. The role of the microbial vironment in Drosophila post-embryonic development. Dev Comp Immunol 64:39-52.
  • Schwarzer, M., K. Makki, G. Storelli, I. Machuca-Gayet, D. Srutkova, P. Hermanova, M. E. Martino, S. Balmand, T. Hudcovic, A. Heddi, J. Rieusset, H. Kozakova, H. Vidal, and F. Leulier. 2016. Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science 351:854-857.





  • Wayland, M. T., A. Defaye, J. Rocha, S. A. Jayaram, J. Royet, I. Miguel-Aliaga, F. Leulier, and P. Cognigni. 2014. "Spotting the differences: Probing host/microbiota interactions with a dedicated software tool for the analysis of faecal outputs in Drosophila." J Insect Physiol 69:126-35.
  • Erkosar Combe, B., A. Defaye, N. Bozonnet, D. Puthier, J. Royet, and F. Leulier. 2014. "Drosophila Microbiota Modulates Host Metabolic Gene Expression via IMD/NF-kappaB Signaling." PLoS One 9:e94729.
  • Meinander, A., C. Runchel, T. Tenev, L. Chen, C.H. Kim, P.S. Ribeiro, M. Broemer, F. Leulier, M. Zvelebil, N. Silverman, and P. Meier. 2012. "Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling." EMBO J 1(12): 2770-83.
  • Storelli, G., A. Defaye, B. Erkosar, P. Hols, J. Royet, and F. Leulier. 2011. "Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing." Cell Metab 14 (3): 403-414.



  • Geuking, P., R. Narasimamurthy, B. Lemaitre, K. Basler, and F. Leulier. 2009. "A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK." PLoS One 4 (11): e7709.
  • Erturk-Hasdemir, D., M. Broemer, F. Leulier, W.S. Lane, N. Paquette, D. Hwang, C.H. Kim, S. Stoven, P. Meier, and N. Silverman. 2009. "Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes." Proc Natl Acad Sci U S A 106 (24): 9779-9784.
  • Defaye, A., I. Evans, M. Crozatier, W. Wood, B. Lemaitre, and F. Leulier. 2009. "Genetic ablation of Drosophila phagocytes reveals their contribution to both development and resistance to bacterial infection." J Innate Immun 1 (4): 322-334.
  • Lhocine, N., P.S. Ribeiro, N. Buchon, A. Wepf, R. Wilson, T. Tenev, B. Lemaitre, M. Gstaiger, P. Meier, and F. Leulier. 2008. "PIMS modulates immune tolerance by negatively regulating Drosophila innate immune signaling." Cell Host Microbe 4 (2): 147-158.
  • Ribeiro, P.S., E. Kuranaga, T. Tenev, F. Leulier, M. Miura, and P. Meier. 2007. "DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells." J Cell Biol 179 (7): 1467-1480.



  • Leulier, F., N. Lhocine, B. Lemaitre, and P. Meier. 2006. "The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection." Mol Cell Biol 26 (21): 7821-7831.
  • Leulier, F., P.S. Ribeiro, E. Palmer, T. Tenev, K. Takahashi, D. Robertson, A. Zachariou, F. Pichaud, R. Ueda, and P. Meier. 2006. "Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery." Cell Death Differ 13 (10): 1663-1674.
  • Stenbak, C.R., J.H. Ryu, F. Leulier, S. Pili-Floury, C. Parquet, M. Herve, C. Chaput, I.G. Boneca, W.J. Lee, B. Lemaitre, and D. Mengin-Lecreulx. 2004. "Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway." J Immunol 173 (12): 7339-7348.
  • Pili-Floury, S., F. Leulier, K. Takahashi, K. Saigo, E. Samain, R. Ueda, and B. Lemaitre. 2004. "In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults." J Biol Chem 279 (13): 12848-12853.
  • Leulier, F., C. Marchal, I. Miletich, B. Limbourg-Bouchon, R. Benarous, and B. Lemaitre. 2003. "Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses."EMBO Rep 4 (10): 976-981.
  • Leulier, F., C. Parquet, S. Pili-Floury, J.H. Ryu, M. Caroff, W.J. Lee, D. Mengin-Lecreulx, and B. Lemaitre. 2003. "The Drosophila immune system detects bacteria through specific peptidoglycan recognition." Nat Immunol 4 (5): 478-484.
  • Leulier, F., S. Vidal, K. Saigo, R. Ueda, and B. Lemaitre. 2002. "Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults." Curr Biol 12 (12): 996-1000.
  • Vidal, S., R.S. Khush, F. Leulier, P. Tzou, M. Nakamura, and B. Lemaitre. 2001. "Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses." Genes Dev 15 (15): 1900-1912.
  • Imboden, M., D. De Saint Jan, F. Leulier, H. Korn, C. Goblet, and P. Bregestovski. 2001. "Isolation and characterization of an alpha 2-type zebrafish glycine receptor subunit." Neuroscience 103 (3): 799-810.
  • Leulier, F., A. Rodriguez, R.S. Khush, J.M. Abrams, and B. Lemaitre. 2000. "The Drosophila caspase Dredd is required to resist gram-negative bacterial infection." EMBO Rep 1 (4): 353-358.


Reviews and Comments

  • Duar RM, Lin XB, Zheng J, Martino ME, Grenier T, Pérez-Muñoz ME, Leulier F, Gänzle M, Walter J. Lifestyles in transition: evolution and natural history of the genus Lactobacillus. FEMS Microbiol Rev. doi: 10.1093/femsre/fux030. [Epub ahead of print]

  • Martino ME, Ma D, Leulier F. 2017. Microbial influence on Drosophila biology. Curr Opin Microbiol. 38:165-170. doi: 10.1016/j.mib.2017.06.004. [Epub ahead of print] Review.

  • Leulier F, MacNeil LT, Lee WJ, Rawls JF, Cani PD, Schwarzer M, Zhao L, Simpson SJ. 2017. Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health. Cell Metab. 25(3):522-534. doi: 10.1016/j.cmet.2017.02.001. Review.
  • Strigini, M., and F. Leulier. 2016. The role of the microbial environment in Drosophila post-embryonic development. Dev Comp Immunol.
  • Ma, D., G. Storelli, M. L. Mitchell, and F. Leulier. 2015. Studying host-microbiota mutualism in Drosophila: harnessing the power of gnotobiotic flies. Biomed J38(4):285-93.
  • Matos, R. C., and F. Leulier. 2014. "Lactobacilli-Host mutualism: "learning on the fly". Microb Cell Fact 13 Suppl 1:S6.
  • Erkosar, B., and F. Leulier. 2014. "Transient adult microbiota, gut homeostasis and longevity: novel insights from the Drosophila model." FEBS Lett 588(22):4250-4257.
  • Storelli, G., M. Tefit, and F. Leulier. 2013. "Metformin, microbes, and aging." Cell Metab 17:809-811.
  • Erkosar, B., G. Storelli, A. Defaye, and F. Leulier. 2013. "Host-intestinal microbiota mutualism: "Learning on the fly". Cell Host Microbe 13:8-14.
  • Leulier, F. 2009. "Tuning down NF-kappaB signaling by DUBs: a fly case." Cell Host Microbe 6 (4): 294-296.
  • Leulier, F., and J. Royet. 2009. "Maintaining immune homeostasis in fly gut." Nat Immunol 10 (9): 936-938.
  • Leulier, F., and B. Lemaitre. 2008. "Toll-like receptors--taking an evolutionary approach." Nat Rev Genet 9 (3): 165-178.
  • Leulier F, Lemaitre B. 2002. "Les récepteurs de la famille TOLL et l’activation de la réponse immunitaire innée". Bulletin de l’association des anciens élèves de l’Institut Pasteur; Mai-Juin 2002, 171: 78-83.
  • Khush, R.S., F. Leulier, and B. Lemaitre. 2002. "Immunology. Pathogen surveillance--the flies have it." Science 296 (5566): 273-275.
  • Khush, R.S., F. Leulier, and B. Lemaitre. 2001. "Drosophila immunity: two paths to NF-kappaB." Trends Immunol 22 (5): 260-264.


Book chapter

  • Kurz, L., and F. Leulier. "Nematode and insect models to assay microbial infectivity, virulence and cytotoxicity." In: Safety Assessment and Regulation of Beneficial Microorganisms. Edited by I. Sundh, A. Wilcks and M. S. Goettel: CAB International. 2012, November.