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  • Shiga, Y., Y. Kato, Y. Aragane-Nomura, T. Haraguchi, T. Saridaki, H. Watanabe, T. Iguchi, H. Yamagata, and M. Averof. 2017. Repeated co-option of a conserved gene regulatory module underpins the evolution of the crustacean carapace, insect wings and other flat outgrowths. bioRxiv:160010.







  • Konstantinides N., and Averof M. 2014. A common cellular basis for muscle regeneration in arthropods and vertebrates. Science 343: 788-91.
  • Gilles A.F., and Averof M. 2014. Functional genetics for all: engineered nucleases, CRISPR and the gene editing revolution. EvoDevo 5: 43.
  • Grillo M., Casanova J., and Averof M. 2014. Development: a deep breath for endocrine organ evolution. Curr Biol 24: R38-40.
  • Rodel C.J., Gilles A.F., and Averof M. 2013. MicroRNAs act as cofactors in bicoid-mediated translational repression. Curr Biol 23: 1579-1584.
  • Sarrazin A.F., Peel A.D., and Averof M. 2012. A segmentation clock with two-segment periodicity in insects. Science 336: 338-341.
  • El-Sherif E., Averof M., and Brown S.J. 2012. A segmentation clock operating in blastoderm and germband stages of Tribolium development. Development 139: 4341-4346.



  • Kontarakis Z., Pavlopoulos A., Kiupakis A., Konstantinides N., Douris V., and Averof M. 2011. A versatile strategy for gene trapping and trap conversion in emerging model organisms. Development 138: 2625-2630.
  • Peel, A.D., and Averof M. 2010. Early asymmetries in maternal transcript distribution associated with a cortical microtubule network and a polar body in the beetle Tribolium castaneum. Dev Dyn 239: 2875-2887.
  • Lynch J.A., Peel A.D., Drechsler A., Averof M., and Roth S. 2010. EGF signaling and the origin of axial polarity among the insects. Curr Biol 20: 1042-1047.
  • Douris V., Telford M.J., and Averof M. 2010. Evidence for multiple independent origins of trans-splicing in Metazoa. Mol Biol Evol 27: 684-693.
  • Pavlopoulos A., Kontarakis Z., Liubicich D.M., Serano J.M., Akam M., Patel N.H., and Averof M. 2009. Probing the evolution of appendage specialization by Hox gene misexpression in an emerging model crustacean. Proc Natl Acad Sci USA 106: 13897-13902.
  • Liubicich D.M., Serano J.M., Pavlopoulos A., Kontarakis Z., Protas M.E., Kwan E., Chatterjee S., Tran K.D., Averof M., and Patel N.H. 2009. Knockdown of Parhyale Ultrabithorax recapitulates evolutionary changes in crustacean appendage morphology. Proc Natl Acad Sci USA 106: 13892-13896.
  • Kontarakis Z., Copf T., and Averof M. 2006. Expression of hunchback during trunk segmentation in the branchiopod crustacean Artemia franciscana. Dev Genes Evol 216: 89-93.
  • Franch-Marro X., Martin N., Averof M., and Casanova J. 2006. Association of tracheal placodes with leg primordia in Drosophila and implications for the origin of insect tracheal systems. Development 133: 785-790.
  • Copf T., Rabet N., and Averof M. 2006. Knockdown of spalt function by RNAi causes de-repression of Hox genes and homeotic transformations in the crustacean Artemia franciscana. Dev Biol 298: 87-94.



  • Pavlopoulos A., and Averof M. 2005. Establishing genetic transformation for comparative developmental studies in the crustacean Parhyale hawaiensis. Proc Natl Acad Sci USA 102: 7888-7893.
  • Pavlopoulos A., Berghammer A.J., Averof M., and Klingler M. 2004. Efficient transformation of the beetle Tribolium castaneum using the Minos transposable element: quantitative and qualitative analysis of genomic integration events. Genetics 167: 737-746.
  • Copf T., Schroder R., and Averof M. 2004. Ancestral role of caudal genes in axis elongation and segmentation. Proc Natl Acad Sci U S A 101: 17711-17715.
  • Copf T., Rabet N., Celniker S.E., and Averof M. 2003. Posterior patterning genes and the identification of a unique body region in the brine shrimp Artemia franciscana. Development 130: 5915-5927.
  • Pavlopoulos A., and Averof M. 2002. Developmental evolution: Hox proteins ring the changes. Curr Biol 12: R291-293.
  • Damen W.G., Saridaki T., and Averof M. 2002. Diverse adaptations of an ancestral gill: a common evolutionary origin for wings, breathing organs, and spinnerets. Curr Biol 12: 1711-1716.
  • Averof M. 2002. Arthropod Hox genes: insights on the evolutionary forces that shape gene functions. Curr Op Genet Dev 12: 386-392.
  • Ligoxygakis P., Strigini M., and Averof M. 2001. Specification of left-right asymmetry in the embryonic gut of Drosophila. Development 128: 1171-1174.



  • Averof M., Rokas A., Wolfe K.H., and Sharp P.M. 2000. Evidence for a high frequency of simultaneous double-nucleotide substitutions. Science 287: 1283-1286.
  • Averof M. 1998. Evolutionary biology. Origin of the spider's head. Nature 395: 436-437.
  • Averof M., and Patel N.H. 1997. Crustacean appendage evolution associated with changes in Hox gene expression. Nature 388: 682-686.
  • Averof M., and Cohen S.M. 1997. Evolutionary origin of insect wings from ancestral gills. Nature 385: 627-630.
  • Averof M. 1997. Arthropod evolution: same Hox genes, different body plans. Curr Biol 7: R634-636.
  • Osorio D., Averof M., and Bacon J.P. 1995. Arthropod evolution: great brains, beautiful bodies. Trends Ecol Evol 10: 449-454.
  • Averof M., and Akam M. 1995. Hox genes and the diversification of insect and crustacean body plans. Nature 376: 420-423.
  • Averof M., and Akam M. 1995. Insect-crustacean relationships: insights from comparative developmental and molecular studies. Phil Trans Roy Soc B 347: 293-303.
  • Akam M., Averof M., Castelli-Gair J., Dawes R., Falciani F., and Ferrier D. 1994. The evolving role of Hox genes in arthropods. Development Suppl: 209-215.
  • Averof M., and Akam M. 1993. HOM/Hox genes of Artemia: implications for the origin of insect and crustacean body plans. Curr Biol 3: 73-78.