Séminaire externe : Alexandra Moreira
de 11:00 à 12:00
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Séminaire externe : Alexandra Moreira (Gene Regulation, i3S and ICBAS, University of Porto, Portugal)
"The hidden power of the 3'UTR in gene expression regulation"
Most human genes go through alternative polyadenylation in different physiological conditions, producing multiple mRNAs with important implications in health and disease. The 3’ untranslated region (3’UTR) of the mRNA, frequently defined by alternative polyadenylation, contains multiple regulatory sequences representing a main hub for gene expression regulation. This regulatory mechanism is partly dictated by RNA-binding proteins (RBPs) that define not only the site of cleavage and polyadenylation of the nascent transcript, but also determine the fate of the mRNA by modulating its stability, transport, subcellular localization, translation and protein localization.
I will present the work my group has been developed on the molecular mechanisms involved in gene expression regulation by alternative polyadenylation in the 3’UTRs and their physiological function, in different model systems. We use a multidisciplinary approach that combines advanced 3’RNA-Seq methodologies and bioinformatics with well-established methods in cellular and molecular biology. I will also present how we are applying this fundamental knowledge to develop new therapeutic tools.
Hôte : Julie Carnesecchi
Jeudi 26 octobre
Salle des thèses