Development and function of the neuromuscular system
2018 Neuron Cover 2016 Drosophila Image Award Finalist
Locomotion is essential for survival as it allows animals to reproduce, find food, or escape predators. Many different modes of locomotion exist in the animal kingdom, such as flying, crawling, swimming or walking, however, among members of the same species, locomotion is very stereotyped and can be modelled in a very precise manner. This invariable pattern of locomotion can be associated with the unvarying morphology of the neuromuscular system. The goal of our team is to study the coordinated development of the three main components of the neuromuscular system -the motoneurons (MNs), muscles and glia- in order to understand how these cells acquire their intricate morphologies to build a functional locomotor system.
The adult Drosophila meets all criteria to achieve our goals with ease; in this model it is possible to study the logic of morphological specification in a small number of easily distinguished cells: ~50 MNs per leg, ~14 muscles per leg and ~280 neuropile glia per leg neuropile, using a vast array of powerful genetic tools, without abandoning an appendage-based locomotion scheme.
Research in our team uses advanced developments in microscopy, cell markers and post-imaging processing combined with new genetic tools and protocols that I have developed and improved to analyse the development of the locomotor system with high resolution as well as the consequences of modifications of the underlying genetic program on locomotion.
we are recruiting!
Undergrad(s) and Master student(s): Please contact us if you want to join the adventure! Please submit a CV, names of at least 2 referees, a statement of past achievements and future research interest to Jonathan Enriquez: email@example.com.
We aim to recruit, see our "we are recruiting" tab for more informations!
current team members
ENRIQUEZ Jonathan Team Leader
LAURENÇON Anne CR1 CNRS
- BOUCHET-COMBE Mathilde IE
- GARVIS Steve IR2
- GUILLERMIN Camille PhD Student
- NIE Ziyan PhD Student
- MORENO Manuela PhD Student
- MENDES Juliette TCN
- DUMAS Anaïs, M1 Student (UCBL)
GUAN Wenyue, Post-doc - 2017/2022
CHEBIL Mona, M1 Student (ENSAT) - 2021
DERVIEUX VIRGILE, M1 Student (UCBL) - 2021
VENKATRAMAN Sandeep, M2 Student (AMRITA) - 2021
BALLAS Eliott, AI Student (ESTBB) - 2021
FOUVRY Thomas, Med Student - 2021
SAINT-CHARLES Pauline, Master (UCBL) - 2021
GARCES Alain, CR (Inserm) - 2018/2020
BELLEMIN Stéphanie, IE (CNRS) - 2017/2020
HAMMOUM Imene, Post doc (CNRS) - 2019
KALBFEIS DIT DARNAS Aurelien, Master (UCBL) - 2019/2020
MOLLET Bastien, Bachelor (ENS) - 2019
CAMACHO RUFINO Miguel, Bachelor (ENS) - 2019
DALL'AGNOL Laure, Master (UCBL) - 2019
PERRIN Julie, BTS - 2019
MERCIER Noémie, Bachelor - 2018
LANGLAIS Emma, Bachelor - 2018
KHOUADER Billel, Bachelor (ENS) - 2018
BILAL Rayssa, Master intern (UCBL) - 2018
ASEI CESCHINO Valentin, Master (UCBL) - 2018