Thesis: Eric SAMARUT
Dec 16, 2013
from 02:30 to 05:00
|Salle des Thèses
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December, 16th, at 02:30 pm, in Salle des Thèses (ENS, Monod campus) Eric Samarut from Vincent Laudet's team will defend his thesis (in french):
"Etude fonctionnelle et évolutive de la voie de l'acide rétinoïque et de la phosphorylation des récepteurs chez le poisson zèbre."
|Retinoic acid (RA) is the main active metabolite of vitamin A and play multiple roles in cellular processes but also during embryonic development. RA acts through two families of nuclear receptors: Retinoic Acid Receptors (RAR) and Retinoid X Receptors (RXR). Those receptors act as ligand-dependent transcription factors and their transcriptional activity is also regulated by phosphorylation processes through kinases activated by RA. During my PhD, I focused on the functional and evolutionary study of RA pathway and of the phosphorylation of RARs using zebrafish (Danio rerio). By studying the activity of the different RAR subtypes in zebrafish, we provide evidences that they can regulate gene expression in a subtype-specific fashion in the early zebrafish embryo. Furthermore, my work showed that during evolution, the acquisition of a phosphorylated residue in RARα promotes the fine-tuned regulation of its activity in mammals. Finally, aiming at deciphering the molecular mechanisms behind dentition diversification in fish, we propose a role for RA signaling in generating morphological novel traits during evolution.