Thesis defense: Yanis Zekri
Dec 20, 2022
from 01:30 to 04:30
LOBACCARO, Jean-Marc Professeur des Universités GReD (Rapporteur)
SACHS, Laurent Directeur de Recherche MNHN (Rapporteur);
GAUTIER-STEIN, Amandine Chargée de Recherche UCBL (Membre);
SEMON, Marie Professeure des Universités LBMC (Membre);
FLAMANT, Frédéric Directeur de Recherche IGFL (Directeur de thèse);
GAUTHIER, Karine Chargée de Recherche IGFL (Co-encadrante de thèse).
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On December 20th, Yanis Zekri of the team of Frédéric Flamant will support his thesis entitled:
"Thyroid hormones target genes, a fresh view through the prism of pangenomic analyses"
Thyroid hormones (TH) act in virtually all organs to coordinate their development during embryonic life and ensure their function in adulthood. In particular, TH regulate the metabolism of brown adipose tissue (BAT), whose ability to increase energy expenditure to produce heat is of interest in the fight against obesity. However, the molecular mechanisms by which TH regulates BAT activity remain enigmatic. This project therefore combines genome-wide analyses and phenotyping of transgenic mice to establish the list of TH target genes and their physiological role in BAT. Given the potential of genome-wide analyses, we have extended the spectrum of our research by compiling, reanalyzing and interpreting all genomic data in the literature that concern the response of murine tissues to TH. The generated TH target gene atlas is a comprehensive overview of TH action in many tissues and constitutes an unprecedented database available to the scientific community. We then proposed a direct application of this atlas by defining TH target genes as biomarkers for the detection of thyroid disruptors. Our genome-wide analyses allowed the detection of low-dose disruptors effects, where conventional tests could not.
This project aims to take a fresh look at classical physiology and toxicology data through the recent prism of genome-wide analyses, in order to bridge the gap between past fundamental knowledge and present and future societal issues.