What is the mouse?
The mouse is the most widely used animal model in the laboratory (60% of animals used in research). For more than a century it has been an irreplaceable model for studying the physiology and development of mammals, including humans.
Why use the mouse in research?
The mouse (Mus Musculus) is the most widely used vertebrate model in research. The mouse has a high genetic homology with humans (99% of its genes have a homologous gene in humans). Its genome is known and the technological tools exist to modify it. It is therefore possible to obtain models that are particularly well suited to the scientific question posed. In addition, the mouse reproduces easily in the laboratory and is small in size. All this makes it an extremely relevant integrated model in many areas of biology.
At the IGFL, we use the mouse to :
- Study the influence of thyroid hormone on brain development and metabolism in adult mice.
- Study the influence of the gut microbiota on post-natal development.
- To analyse how the circadian clock regulates all physiological functions throughout the day.
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