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Angiogenesis and cancer
|  | Neovasculature development is a crucial step in solid tumor growth and targeting tumor angiogenesis is a way to fight cancer. Several collagen-derived anti-angiogenic factors (CDAF) that are released upon matrix breakdown have been characterized with proven benefits in cancer cure. Collagen V is overexpressed in breast and lung cancers but its role in cancer physiopathology is not fully understood. By combining in vitro, ex vivo and in vivo approaches, we are characterizing domains derived from collagen V proteolysis, with the objective to examine their potential implication in tumor growth and angiogenesis. | |
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