Directory
Bioscketch
Jonathan Enriquez, Ph.D.
Group Leader – Development and Function of Neuromuscular System
+33.7.68.66.90.89
PERSONAL INFORMATION
ORCID: 0000-0002-7679-4674
Research ID: M-6945-2015
Date of birth: 15 March 1980
Nationality: French
MAIN SCIENTIFIC CONTRIBUTIONS
My research combines genetics, molecular biology, imaging, post-imaging processing, computational biology, and behavioural approaches. I use Drosophila melanogaster to discover new biological concepts and developmental mechanisms. Over the past decade, I became an expert on the development of three main components of the locomotor system: muscle, glial cells and motoneurons. I discovered part of the molecular machinery controlling the deterministic program that defines the morphological identity of muscle (Enriquez et al, 2010, 2012 and 2015), and demonstrated for the first time that motoneurons express at the single cell level a code of transcription factors controlling the morphology of their dendritic arbor and axonal targeting (Enriquez et al, 2015). I achieved this goal by developing a new technique (MARCMbow, Enriquez et al, 2015) to visualize motoneurons at the single cell level and modify their genome at the same time. As a group leader, I expanded my work to the study of another component of the locomotor system: glial cells. Developing a new technique (cisMARCM, Enriquez et al, 2018), I demonstrated that the development of glia is not deterministic but plastic and stochastic. This work was highlighted in the 2018 F1000Prime Recommendation. It has been recently demonstrated that this logic of development is conserved during evolution (Solène Clavreul et al., 2019). Over the past decade, my research, teaching and administrative activities have allowed me to develop the skills essential for the success of the DEVandMove proposal.
POSITIONS AND EMPLOYMENT
INSTITUTIONAL RESPONSIBILITIES
2018-2019 Facility manager of the arthro-tools facility at ENS Lyon. The facility develops innovative research projects based on arthropod models for 10 teams and organize monthly meetings.
PREVIOUS POSITIONS
2015-2016 Associate Research Scientist
Department of Biochemistry & Molecular Biophysics, Columbia University, New York, USA
Transcriptional identity code of adult motoneuron in Drosophila
2010-2015 Post-Doctoral Research Scientist
Mann Lab, Department of Biochemistry & Molecular Biophysics, Columbia University
Transcriptional identity code of adult motoneuron in Drosophila
2005 Undergraduate Internship (European Master of Genetics, 8 months)
Ecole Normale Supérieure of Paris, France
Role of the interaction centrosome-cortex in the regulation of cell polarity in Drosophila.
Mentor: François Schweisguth, Ph.D.
2004 Undergraduate Internship (European Master of Genetics, 6 months)
Steller Lab, Rockefeller University, New York, USA
Characterization of genes implicated in apoptosis in Drosophila.
Mentor: Bertrand Mollereau, Ph.D.
2003 Undergraduate Internship (European License of Genetics, 3 months)
Institute J. Monod, Paris, France
Study of apoptosis inhibition by Chlamydia pneumoniae in epithelial cells.
Mentor: David Ojcius, Ph.D.
2002 Undergraduate Internship (DEUG, 1 months)
Lyonnaise des Eaux/Suez Environnement, Bordeaux, France
Study of Densadeg and research of the optimal concentration of iron chloride for flocculation.
EDUCATION
2020 HDR: Habilitation à diriger les Recherches.
2010 PhD, Center of Developmental Biology, University of Toulouse 3, France
"Specification of muscle identity in Drosophila: The role of the Hox, Col/EBFand D- MyoD transcription factors"
PhD Supervisor: Alain Vincent, PhD.
2005 European Master of Genetics, University of Jussieu-Paris 7, France.
2005 Magistère of Genetics (Selective school in France which awards the diploma based on a competitive evaluation process), University of Jussieu-Paris 7, France.
TEACHING ACTIVITIES
2020 Member of the evaluating comity to evaluate oral presentations of Master 2 students
2019 Invited lecturer, myogenis in vertebrate and invertebrate courses for graduate students, ENS of Lyon, France, 4 hours
Member of the evaluating comity to evaluate oral presentations of Master 2 students
2018 Invited lecturer, development of Drosophila melanogaster courses for undergraduate students, ENS of Lyon, France, 15 hours
2006-2008 Graduate Teaching Assistant, developmental biology courses for graduates and undergraduate students, University of Toulouse 3, France, 64 hours/year
FELLOWSHIPS
Total number (6): 2 postdoctoral, 2 doctoral, 2 predoctoral
2013-2015 Post-Doctoral fellowship, French Association against Muscular Dystrophy, France
2010-2012 Philippe Foundation Fellowship, USA
2008-2009 Doctoral fellowship, AFM (French Muscular Dystrophy Association), France
2005-2008 Doctoral fellowship, allocated to the best Master students in France
2004-2005 Pre-doctoral fellowship, French Ministry for Research and Technology, France
2004 Undergraduate Fellowship, French State internship at the Rockefeller University, USA
HONORS AND AWARDS
2019 Camille Guillemin, my PhD student, obtained the highly competitive master prize of the French society of Myology in November 2018. The selection was based on her CV, project and scientific quality of the supervisor. Prize: 1000 euros for her and 9000 euros for the laboratory.
2016 Finalist of Drosophila Image Award https://drosophila-images.org/2016-2/
GRANTS
Total funding obtained through 4 Grants as Principal Investigator: 738 K€
2018/2020 Elan ERC: awarded by the Idex program of Lyon University to selected scientist with potential to obtain ERC grants.
Role: Principal Investigator 42 000€
2018-2020 Winner of the highly competitive Atip-Avenir fellowship co-sponsored with AFM Association
Role: Principal Investigator: 360 000€
2017-2020 ANR JCJC (286 783€). Note: declined as it overlapped with ATIP Avenir grant
2017-2019 Foundation of Medical Research. 296 600€
2015-2016 Starter Grant, to Amyotrophic Lateral Sclerosis Association. 40,000$
SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS
Current supervision in the lab: 1 PhD, and 1 Postdocs.
Past supervision in the lab: 4 Master Students
Current defence committees: Graduate Student advisor of 3 students, ENS of Lyon, France.
Co-supervised: 3 PhDs, 2 Master Students and 1 Technician in Mann lab, Columbia University, New York, USA. 2 PhDs in Vincent lab, University of Toulouse 3, France.
Thesis Jury: Examiner of 3 PhD Defenses, 2 in Clermont Auvergne University (2018-2019), 1 in Montpellier University (2018), France
MEMBERSHIPS OF SCIENTIFIC SOCIETIES
Member of the French Society of Myology (since 2019);
Member of the French Society of developmental Biology (since 2017);
Member of the Magistère of genetic association (since 2016).
INVITED SPEAKER AT INTERNATIONAL INSTITUTES
Club Neuromusculaire Auvergne-Rhône/Alpes, France, ‘Building the correct innervation’, 2019
Center of Developmental Biologie, Toulouse, France, ‘Motoneurons and Glia: Common origins yet divergent modes of development’, 2019
Institut de Myologie, Paris, France, ‘Making unique connections’, 2018
Institut Valrose de Nice, France, ‘Motoneurons and glia: Common origins yet divergent modes of development’, 2018
The Munich Center for Neurosciences, Germany, ‘Motoneurons and Glia: Common origins yet divergent modes of development’, 2017
Institute for Research in Biomedicine (IRB), Barcelona, Spain, ‘Motoneurons and Glia: Common origins yet divergent modes of development’, 2017
Club Neuromusculaire Auvergne-Rhône/Alpes, Lyon, France, ‘Development of the locomotor system’ 2017
The Fly Eye Club Meeting at Rockefeller University, New York, USA, ‘Making a motoneuron unique’, 2016
Memorial Sloan Ketering Cancer Center, USA, ‘Making a motoneuron unique’, 2014
ORAL COMMUNICATIONS AT INTERNATIONAL MEETINGS
Joint meeting of the Portuguese, Spanish and French societies for Developmental Biologie, Porto, Portugal, November 2018
Jacques Monod Conference “Building, repairing and evolving biological tissues”, Roscoff, France, 2015
The 56th Annual Drosophila Research Conference, Chicago, USA, 2015
The Developmental French Society Meeting in Toulouse, France, 2009
POSTER COMMUNICATION
Modeling cell fate, Roscoff, France, September 2018
Gordon Research Conference on Neural Development, Newport, USA, 2016
The 56th Annual Drosophila Research Conference, Chicago, USA, 2015
The Neurobiology of Drosophila Meeting, Cold Spring Harbor, USA, 2013
The 8th FENS Forum of Neuroscience, Barcelona, Spain, 2012
‘Making Muscle in the Embryo and the Adult’ Meeting at Columbia University, New York, USA, 2009
ORGANISATION OF SCIENTIFIC MEETINGS
2021 Member of the organizer committee for the 27th European Drosophila Research Conference (EDRC), Lyon 2021. Expected number of participants: 700
2020 Member of the scientific committee for the 2nd MuSkLE conference, Saint-Etienne 2020. Expected number of participants: 120 (cancelled due to COVID19)
2019 Organizer of the 33rd Annual French Drosophila Conference, Lyon 2019. Number of participants: 90
2009 Assisted PhD adviser, Alain Vincent, in organising the Developmental French Society Meeting in Toulouse, France. Number of participants: 200
REVIEWING ACTIVITIES
Journal review:
Reviewer for Developmental Biology and Neural Development journals
Review for funding agencies:
Reviewer of the French National French Agency (ANR);
Scientific Expert member of the molecular and cellular neuroscience panel of ANR;
Reviewer for the 2020 Research Grant awards from the Human Frontier Science Program Organization.
PUBLICATIONS
1. Babski, H., Jovanic, T., Surel. C., Yoshikawa, S., Zwart, MF., Valmier, J., Thomas, JB., Enriquez, J., Carroll P, Garcès, A. A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion in Drosophila. Nat Commun. 2019 Oct 22;10(1):4796. (0 citation)
2. Guan, W., Venkatasubramanian, L., Baek, M., Mann, R.S., and Enriquez, J. (2018). Visualize Drosophila Leg Motor Neuron Axons Through the Adult Cuticle. corresponding author. J. Vis. Exp. JoVE. (1 citation)
3. Enriquez, J., Rio, L.Q., Blazeski, R., Bellemin, S., Godement, P., Mason, C., and Mann, R.S. (2018). Differing Strategies Despite Shared Lineages of Motor Neurons and Glia to Achieve Robust Development of an Adult Neuropil in Drosophila. Co- corresponding author. Neuron 97, 538–554.e5. (11 citations)
- Cover article: https://www.cell.com/neuron/issue?pii=S0896-6273(17)X0004-4#fullCover
- Hiesinger P: F1000Prime Recommendation 07 Aug 2018; 10.3410/f.732571328.793548920
- CNRS press: https://insb.cnrs.fr/fr/cnrsinfo/construire-un-systeme-nerveux-fonctionnel
4. Enriquez, J., Venkatasubramanian, L., Baek, M., Peterson, M., Aghayeva, U., and Mann, R.S. (2015). Specification of individual adult motor neuron morphologies by combinatorial transcription factor codes. Co- corresponding author. Neuron 86, 955–970. (26 citations)
- Drosophila image award: https://drosophila-images.org/2016-2/
- Highlight: Tuthill, J. (2015). A framework for fatalism in the fly. J. Exp. Biol. 218, 3349–3350.
- Commented in a chapter book: Hobert, O. (2016). Chapter Twenty-Five - Terminal Selectors of Neuronal Identity. In Current Topics in Developmental Biology, P.M. Wassarman, ed. (Academic Press), pp. 455–475.
5. Baek, M., Enriquez, J., and Mann, R.S. (2013). Dual role for Hox genes and Hox co-factors in conferring leg motoneuron survival and identity in Drosophila. Dev. Camb. Engl. 140, 2027–2038. (31 citations)
6. Boukhatmi, H., Frendo, J.L., Enriquez, J., Crozatier, M., Dubois, L., and Vincent, A. (2012). Tup/Islet1 integrates time and position to specify muscle identity in Drosophila. Dev. Camb. Engl. 139, 3572–3582. (18 citations).
7. Enriquez, J., de Taffin, M., Crozatier, M., Vincent, A., and Dubois, L. (2012). Combinatorial coding of Drosophila muscle shape by Collier and Nautilus. Dev. Biol. 363, 27–39. (20 citations)
8. Enriquez, J., and Vincent, A. (2010). Segmental variations in the patterns of somatic muscles: what roles for Hox? Fly (Austin) 4, 249–252. (1 citation)
9. Enriquez, J., Boukhatmi, H., Dubois, L., Philippakis, A.A., Bulyk, M.L., Michelson, A.M., Crozatier, M., and Vincent, A. (2010). Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo. Dev. Camb. Engl. 137, 457–466. (27 citations)
10. Dubois, L., Enriquez, J., Daburon, V., Crozet, F., Lebreton, G., Crozatier, M., and Vincent, A. (2007). Collier transcription in a single Drosophila muscle lineage: the combinatorial control of muscle identity. Dev. Camb. Engl. 134, 4347–4355 . (48)