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Development and function of the neuromuscular system



2018 Neuron Cover        2016 Drosophila Image Award Finalist

Our research

Locomotion is essential for survival as it allows animals to reproduce, find food, or escape predators. Many different modes of locomotion exist in the animal kingdom, such as flying, crawling, swimming or walking, however, among members of the same species, locomotion is very stereotyped and can be modelled in a very precise manner. This invariable pattern of locomotion can be associated with the unvarying morphology of the neuromuscular system. The goal of our team is to study the coordinated development of the three main components of the neuromuscular system -the motoneurons (MNs), muscles and glia- in order to understand how these cells acquire their intricate morphologies to build a functional locomotor system.

Our system

The adult Drosophila meets all criteria to achieve our goals with ease; in this model it is possible to study the logic of morphological specification in a small number of easily distinguished cells: ~50 MNs per leg, ~14 muscles per leg and ~280 neuropile glia per leg neuropile, using a vast array of powerful genetic tools, without abandoning an appendage-based locomotion scheme.

our techniques

Research in our team uses advanced developments in microscopy, cell markers and post-imaging processing combined with new genetic tools and protocols that I have developed and improved to analyse the development of the locomotor system with high resolution as well as the consequences of modifications of the underlying genetic program on locomotion.

we are recruiting!

Undergrad(s) and Master student(s): Please contact us if you want to join the adventure! Please submit a CV, names of at least 2 referees, a statement of past achievements and future research interest to Jonathan Enriquez:

We aim to recruit, see our "we are recruiting" tab for more informations! 


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current team members

ENRIQUEZ Jonathan Team Leader


GUILLERMIN Camille PhD Student 
NIE Ziyan PhD Student
MORENO Manuela PhD Student 
MOINI Zoé, M1 Student (UCBL)


DUMAS Anaïs, M1 Student (UCBL)

GUAN Wenyue, Post-doc - 2017/2022

CHEBIL Mona, M1 Student (ENSAT) - 2021

DERVIEUX VIRGILE, M1 Student (UCBL) - 2021

VENKATRAMAN Sandeep, M2 Student (AMRITA) - 2021

BALLAS Eliott, AI Student (ESTBB) - 2021

FOUVRY Thomas, Med Student - 2021

SAINT-CHARLES Pauline, Master (UCBL) - 2021

GARCES Alain, CR (Inserm) - 2018/2020

BELLEMIN Stéphanie, IE (CNRS) - 2017/2020

HAMMOUM Imene, Post doc (CNRS) - 2019

KALBFEIS DIT DARNAS Aurelien, Master (UCBL) - 2019/2020

MOLLET Bastien, Bachelor (ENS) - 2019

CAMACHO RUFINO Miguel, Bachelor (ENS) - 2019

DALL'AGNOL Laure, Master (UCBL) - 2019

PERRIN Julie, BTS - 2019

MERCIER Noémie, Bachelor - 2018

LANGLAIS Emma, Bachelor - 2018

KHOUADER Billel, Bachelor (ENS) - 2018

BILAL Rayssa, Master intern (UCBL) - 2018

ASEI CESCHINO Valentin, Master (UCBL) - 2018


Our funding

Fondation pour la recherche médicale — Wikipédia      Découvrez le programme du Téléthon 2019 :: Monteux