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K. PADMANABHAN - Molecular and epigenetic regulation of biological clocks

Molecular and epigenetic regulation of biological clocks

 

 

Current lab members:

Helene Boyer (PhD, ENS)

Eric Folco (Postdoc)

Pauline Abrial (AI)

Jugal Mohapatra (Summer Intern- IIT Kharagpur)

Yann Sakref (L3, ENS Lyon)

Sarah Heintz (Stagiare, 2nd yr, ESTBB)

co-supervisor : Lorrie Ramos (PhD student, IAB, Grenoble)

 

Former trainees/members:

Shannin Arenales Castillo (Masters student year 1), ENS Biosciences

Isahak Saidi (Masters student, year 2) ; currently PhD student at Champalimaud Neuroscience Programme.

Lies Chikhaoui (M1 student, Univ Lyon)

Nicolas McAdams (M2 student, Univ Lyon)

Laurence Canaple (IR2, CNRS)

Aysegul Ors (PhD, Grenoble and Bilkent University)

Stella Chausheva (currently- PhD student, Medical University of Vienna)

 

 

 

Key References:

  1. Padmanabhan K#.  and Billaud M. Desynchronization of Circadian clocks in Cancer : A metabolic and epigenetic connection. Front Endocrinol,  8 :136. 2017. 
  2. Ors A, Papin C, Favier B, Roulland Y, Dalkara D, Ozturk M, Hamiche A, Dimitrov S and Padmanabhan K#. Histone H3.3 regulates mitotic progression in mouse embryonic fibroblasts. Biochemistry and Cell Biology, 2017, doi: 10.1139/bcb-2016-019. 

    http://www.nrcresearchpress.com/eprint/MVAZKjrbrGY2e2Ji7ns7/full

3. Roulland Y , Ouararhni K , Naidenov M , Ramos L , Shuaib M , Syed SH , Lone IN, Boopathi R, Fontaine E , Papai G ,Tachiwana H,
    Gautier T , Skoufias D , Padmanabhan K , Bednar J , Kurumizaka H,  Schultz P, Angelov D , Hamiche A & Dimitrov S. The flexible
    ends of CENP-A nucleosome are required for mitotic fidelity. Molecular Cell. 32081-7(16).  2016

4. Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C and
    Hamiche A. ANP32E is a histone chaperone that removes H2A.Z from chromatin. Nature. 505: 648-53. 2014

5. Padmanabhan K, Robles M, Westerling T and Weitz CJ. Feedback regulation of transcriptional termination by the mammalian circadian       clock PERIOD complex. Science. 337: 599-602. 2012


6. Robles M, Boyault C, Knutti D, Padmanabhan K and Weitz CJ. Identification of RACK1 and protein kinase Calpha as integral      
    components of the mammalian circadian clock. Science. 327: 463-6, 2010.

The lab's research benefits from funding from:

Team members

 

PADMANABHAN Kiran

Team leader, CR1 ATP-INSERM 04 26 73 13 60
     

CANAPLE Laurence

IR, CNRS 04 26 73 13 59

FOLCO Eric

post-Doc 04 26 73 13 61

SAIDI Isahak

M2 student 04 26 73 13 61

Publications

2017

  • Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection.
    Kiran Padmanabhan# and  Marc Billaud.
    Frontiers in Endocrinology, 19 June 2017 | https://doi.org/10.3389/fendo.2017.00136
  • Histone H3.3 regulates mitotic progression in mouse embryonic fibroblasts. 
    Ors A, Papin C, Favier B, Roulland Y, Dalkara D, Ozturk M, Hamiche A, Dimitrov S and Padmanabhan K#.
    Biochemistry and Cell Biology2017 doi :10.1139/bcb-2016-0190

2016

  • The flexible ends of CENP-A nucleosome are required for mitotic fidelity.
    Roulland Y , Ouararhni K , Naidenov M , Ramos L , Shuaib M , Syed SH , Lone IN, Boopathi R, Fontaine E , Papai G ,Tachiwana H, Gautier T , Skoufias D , Padmanabhan K , Bednar J , Kurumizaka H,  Schultz P, Angelov D , Hamiche A & Dimitrov S.  
    Molecular Cell. 32081-7(16).

2014

  • ANP32E is a histone chaperone that removes H2A.Z from chromatin.
    Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C and Hamiche A.  
    Nature. 505: 648-53.

2012

  • Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.
    Padmanabhan K, Robles M, Westerling T and Weitz CJ. 
    Science. 337: 599-602.

2010

  • Identification of RACK1 and protein kinase Calpha as integral components of the mammalian circadian clock. 
    Robles M, Boyault C, Knutti D, Padmanabhan K and Weitz CJ.
    Science. 327: 463-6, 2010.
  • Pumilio-2 controls translation by competing with eIF4e for 7-methyl guanosine cap recognition. 
    Cao Q, Padmanabhan K and Richter JD.
    RNA. 16(2):338-48, 2010.

2007

  • Translational unmasking of Emi2 directs cytostatic factor arrest in meiosis II.
    Tung JJ*, Padmanabhan K*, Hansen D, Richter JD and Jackson P.  
    Cell Cycle 6 (6): e1-e7, 2007. (*equal contribution)

2006

  • Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation.
    Padmanabhan K and Richter JD. 
    Genes Dev. 20 (2): 199-209, 2006.

2002

  •  A preliminary investigation of modified alginates as a matrix for gene transfection in a HeLa cell model.
    Padmanabhan K and Smith TJ.
    Pharm Dev Technol 7 (1): 97-101, 2002

 

Pictures from the team

Image Photo_KPadmanabhan_90x90
Image PNG image Photo_KPadmanabhan_150x196
Image PNG image Figure 1: Circadian expression of the Rev-Luc transgene in mice by bioluminescence imaging.
Figure 1: Circadian expression of the Rev-Luc transgene in mice by bioluminescence imaging. Left, representative luminescent imaging of the same anesthetized Rev-Luc reporter transgenic mice over time for the ventral and dorsal faces. Right, quantitative bioluminescence radiance as a function of zeitgeber time for ventral (n=34) and dorsal (n=15) expositions. The fitted dark line represents the mean cosine wave of best fit with a 24 h period. (Canaple et al, Unpublished)
Image PNG image Figure 2. Real time bioluminescence
Image PNG image Ligue logo
Image JPEG image Atip avenir
Image PNG image Inserm