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Short Bio Team Leader

Group Leader: Comparative developmental biology and regeneration

 Background

  • PhD, University of Cambridge, UK / 1994
  • Post-doc, EMBL Heidelberg, Germany / 1995-1997
  • Group leader at IMBB Crete, Greece / 1999-2012
  • Group leader at IGFL, Lyon, France / since 2012

 

Main achievementS

  • Revealed changes in the expression of Hox genes that underpin evolutionary changes in the body of crustaceans.
  • Demonstrated the existence of a segmentation clock in insects, indicating that molecular oscillators are a common feature of segmentation in arthropods and vertebrates.
  • Established transgenesis, CRISPR-mediated gene editing and live imaging in the emerging experimental models Parhyale and Tribolium.
  • Established a new experimental model for studying regeneration, where genetic markers and live imaging can be used to discover the progenitor cells and cell dynamics of leg regeneration.

 

Selected recent publications

  • Alwes, Enjolras and Averof (2016) Live imaging reveals the progenitors and cell dynamics of limb regeneration. eLife 5: e19766
  • Konstantinides and Averof (2014) A common cellular basis for muscle regeneration in arthropods and vertebrates. Science 343: 788-791
  • Sarrazin, Peel and Averof (2012) A segmentation clock with two-segment periodicity in insects. Science 336: 338-341
  • Pavlopoulos et al. (2009) Probing the evolution of appendage specialization by Hox gene mis-expression in an emerging model crustacean. PNAS 106: 13897-13902