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Prenatal exposure to paraquat and nanoscaled TiO2 aerosols alters the gene expression of the developing brain

Author(s) : Hamdaoui Q, Zekri Y, Richard S, Aubert D, Guyot R, Markossian S, Gauthier K, Gaie-Levrel F, Bencsik A, Flamant F,
Journal : Chemosphere
2022

Functional definition of thyroid hormone response elements based on a synthetic STARR-seq screen

Author(s) : Flamant F, Zekri Y, Guyot R,
Journal : Endocrinology
2022

Assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors

Author(s) : Zekri Y, Agnol L, Flamant F, Guyot R,
Journal : iScience
2021

Central vs. Peripheral Action of Thyroid Hormone in Adaptive Thermogenesis: A Burning Topic

Author(s) : Zekri Y, Flamant F, Gauthier K,
Journal : Cells
2021

PRMT1 Is Critical for the Transcriptional Activity and the Stability of the Progesterone Receptor.

Author(s) : Malbeteau L, Poulard C, Languilaire C, Mikaelian I, Flamant F, Le Romancer M, Corbo L,
Journal : iScience
2020

Two novel cases of resistance to thyroid hormone due to THRA mutation (RTHα)

Author(s) : Le Maire A, Bouhours-Nouet N, Soamalala J, Delphine M, Paloni M, Guee L, Heron D, Mignot C, Illouz F, Joubert F, Briet C, Rodien P, Bourguet W, Flamant F, Guyot R,
Journal : Thyroid
2020

A Pivotal Genetic Program Controlled by Thyroid Hormone during the Maturation of GABAergic Neurons

Author(s) : Richard S, Guyot R, Rey-Millet M, Prieux M, Markossian S, Aubert D, Flamant F,
Journal : iScience
2020

Protocols for Studying How Thyroid Hormone Receptors Trigger Adaptive Thermogenesis in Mice.

Author(s) : Gauthier K,
Journal : Methods Mol Biol
2018

Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment.

Author(s) : Manka P, Coombes J, Boosman R, Gauthier K, Papa S, Syn W,
Journal : Cancer Lett
2018

Thyroid Hormone Receptor Alpha Deletion in ApoE-/- Mice Alters the Arterial Renin-Angiotensin System and Vascular Smooth Muscular Cell Cholesterol Metabolism

Author(s) : Neggazi S, Canaple L, Hamlat N, Gauthier K, Samarut J, Bricca G, Aouichat-Bouguerra S, Beylot M,
Journal : J Vasc Res
2018

Regulation of T3 Availability in the Developing Brain: The Mouse Genetics Contribution

Author(s) : Richard S, Flamant F,
Journal : Frontiers in Endocrinology
2018

CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone

Author(s) : Markossian S,
Journal : Thyroid
2018

Two Protocols to Study the Interactions of Thyroid Hormone Receptors with Other Proteins and Chromatin

Author(s) : Guan W, Guyot R, Flamant F,
2018

Electroporation of mice zygotes with dual guide RNA/Cas9 complexes for simple and efficient cloning-free genome editing.

Author(s) : Teixeira M, Py B, Bosc C, Laubreton D, Moutin M, Marvel J, Flamant F, Markossian S,
Journal : Sci Rep
2018

Neuronal expression of a thyroid hormone receptor alpha mutation alters mouse behaviour

Author(s) : Richard S, Aguilera N, Thevenet M, Dkhissi-Benyahya O, Flamant F,
Journal : Behav Brain Res
2017

Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin

Author(s) : Guan W, Guyot R, Samarut J, Flamant F, Wong J, Gauthier K,
Journal : Proc Natl Acad Sci U S A
2017

Genetic Investigation of Thyroid Hormone Receptor Function in the Developing and Adult Brain

Author(s) : Flamant F, Gauthier K, Richard S,
Journal : Curr Top Dev Biol
2017

Thyroid hormone signaling pathways. Time for a more precise nomenclature

Author(s) : Flamant F, Cheng S, Hollenberg A, Moeller L, Samarut J, Wondisford F, Yen P, Refetoff S,
Journal : Endocrinology
2017

Neuronal expression of a thyroid hormone receptor alpha mutation alters mouse behaviour

Author(s) : Richard S, Aguilera N, Thevenet M, Dkhissi-Benyahya O, Flamant F,
Journal : Behav Brain Res
2016

CRISPR/Cas9: a breakthrough in generating mouse models for endocrinologists

Author(s) : Markossian S, Flamant F,
Journal : J Mol Endocrinol
2016

Futures Challenges in Thyroid Hormone Signaling Research

Author(s) : Flamant F,
Journal : Front Endocrinol (Lausanne)
2016

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Author(s) : Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Muller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sanchez-Garrido M, Liu P, Tuckermann J, Malehmir M, Healy M, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm K, Biebermann H, Doring Y, Weber C, Habegger K, Keuper M, Gelfanov V, Liu F, Kohrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Hofmann S, Yang B, Tschop M, DiMarchi R, Muller T,
Journal : Cell
2016

Unique features of a global human ectoparasite identified through sequencing of the bed bug genome

Author(s) : Benoit J, Adelman Z, Reinhardt K, Dolan A, Poelchau M, Jennings E, Szuter E, Hagan R, Gujar H, Shukla J, Zhu F, Mohan M, Nelson D, Rosendale A, Derst C, Resnik V, Wernig S, Menegazzi P, Wegener C, Peschel N, Hendershot J, Blenau W, Predel R, Johnston P, Ioannidis P, Waterhouse R, Nauen R, Schorn C, Ott M, Maiwald F, Johnston J, Gondhalekar A, Scharf M, Peterson B, Raje K, Hottel B, Armisen D, Crumiere A, Refki P, Santos M, Sghaier E, Viala S, Khila A, Ahn S, Childers C, Lee C, Lin H, Hughes D, Duncan E, Murali S, Qu J, Dugan S, Lee S, Chao H, Dinh H, Han Y, Doddapaneni H, Worley K, Muzny D, Wheeler D, Panfilio K, Vargas Jentzsch I, Vargo E, Booth W, Friedrich M, Weirauch M, Anderson M, Jones J, Mittapalli O, Zhao C, Zhou J, Evans J, Attardo G, Robertson H, Zdobnov E, Ribeiro J, Gibbs R, Werren J, Palli S, Schal C, Richards S,
Journal : Nat Commun
2016

Thyroid Hormone Signaling in the Mouse Retina

Author(s) : Arbogast P, Flamant F, Godement P, Glosmann M, Peichl L,
Journal : PLoS One
2016

TRalpha receptor mutations extend the spectrum of syndromes of reduced sensitivity to thyroid hormone

Author(s) : Vlaeminck-Guillem V, Espiard S, Flamant F, Wemeau J,
Journal : Presse Med
2015

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance

Author(s) : Ozmadenci D, Feraud O, Markossian S, Kress E, Ducarouge B, Gibert B, Ge J, Durand I, Gadot N, Plateroti M, Bennaceur-Griscelli A, Scoazec J, Gil J, Deng H, Bernet A, Mehlen P, Lavial F,
Journal : Nat Commun
2015

Editorial: "Thyroid Hormone in Brain and Brain Cells"

Author(s) : Flamant F, Koibuchi N, Bernal J,
Journal : Front Endocrinol (Lausanne)
2015

Human odontoblast-like cells produce nitric oxide with antibacterial activity upon TLR2 activation

Author(s) : Farges J, Bellanger A, Ducret M, Aubert-Foucher E, Richard B, Alliot-Licht B, Bleicher F, Carrouel F,
Journal : Front Physiol
2015

A Novel Mutation in THRA Gene Associated With an Atypical Phenotype of Resistance to Thyroid Hormone

Author(s) : Espiard S, Savagner F, Flamant F, Vlaeminck-Guillem V, Guyot R, Munier M, d'Herbomez M, Bourguet W, Pinto G, Rose C, Rodien P, Wemeau J,
Journal : J Clin Endocrinol Metab
2015

A temporary compendium of thyroid hormone target genes in brain

Author(s) : Chatonnet F, Flamant F, Morte B,
Journal : Biochim Biophys Acta
2015

The targeted inactivation of TRbeta gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production

Author(s) : Selmi-Ruby S, Bouazza L, Obregon M, Conscience A, Flamant F, Samarut J, Borson-Chazot F, Rousset B,
Journal : Endocrinology
2014

Deciphering direct and indirect influence of thyroid hormone with mouse genetics

Author(s) : Picou F, Fauquier T, Chatonnet F, Richard S, Flamant F,
Journal : Mol Endocrinol
2014

Toxicogenomic analysis of the ability of brominated flame retardants TBBPA and BDE-209 to disrupt thyroid hormone signaling in neural cells

Author(s) : Guyot R, Chatonnet F, Gillet B, Hughes S, Flamant F,
Journal : Toxicology
2014

Nongenomic, TRbeta-dependent, thyroid hormone response gets genetic support

Author(s) : Gauthier K, Flamant F,
Journal : Endocrinology
2014

[Comparison between the centrifugation on MPA C10 (Roche Diagnostics) and the centrifugation according recommendations of GEHT (Groupe d'etude de l'hemostase et de la thrombose) for the daily hemostasis assays]

Author(s) : Flamant F, Borg J, Lenormand B, Le Cam-Duchez V,
Journal : Ann Biol Clin (Paris)
2014

Purkinje cells and Bergmann glia are primary targets of the TRalpha1 thyroid hormone receptor during mouse cerebellum postnatal development

Author(s) : Fauquier T, Chatonnet F, Picou F, Richard S, Fossat N, Aguilera N, Lamonerie T, Flamant F,
Journal : Development
2014

Autonomous functions of murine thyroid hormone receptor TRalpha and TRbeta in cochlear hair cells

Author(s) : Dettling J, Franz C, Zimmermann U, Lee S, Bress A, Brandt N, Feil R, Pfister M, Engel J, Flamant F, Ruttiger L, Knipper M,
Journal : Mol Cell Endocrinol
2014

Chondrocytes play a major role in the stimulation of bone growth by thyroid hormone

Author(s) : Desjardin C, Charles C, Benoist-Lasselin C, Riviere J, Gilles M, Chassande O, Morgenthaler C, Laloe D, Lecardonnel J, Flamant F, Legeai-Mallet L, Schibler L,
Journal : Endocrinology
2014

Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells

Author(s) : Chatonnet F, Livera G, Fumel B, Fouch E, Flamant F,
Journal : Mol Reprod Dev
2014

Thyroid hormone receptors: the challenge of elucidating isotype-specific functions and cell-specific response

Author(s) : Flamant F, Gauthier K,
Journal : Biochim Biophys Acta
2013

Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells

Author(s) : Chatonnet F, Guyot R, Benoit G, Flamant F,
Journal : Proc Natl Acad Sci U S A
2013

[Thyroid hormone T3 triggers the developmental loss of axonal regenerative capacity]

Author(s) : Avci H, Flamant F, Dusart I,
Journal : Med Sci (Paris)
2013

A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation

Author(s) : Picou F, Fauquier T, Chatonnet F, Flamant F,
Journal : Mol Endocrinol
2012

Genome-wide search reveals the existence of a limited number of thyroid hormone receptor alpha target genes in cerebellar neurons

Author(s) : Chatonnet F, Guyot R, Picou F, Bondesson M, Flamant F,
Journal : PLoS One
2012

Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor alpha1 and kruppel-like factor 9 in Purkinje cells

Author(s) : Avci H, Lebrun C, Wehrle R, Doulazmi M, Chatonnet F, Morel M, Ema M, Vodjdani G, Sotelo C, Flamant F, Dusart I,
Journal : Proc Natl Acad Sci U S A
2012

Severe impairment of cerebellum development in mice expressing a dominant-negative mutation inactivating thyroid hormone receptor alpha1 isoform

Author(s) : Fauquier T, Romero E, Picou F, Chatonnet F, Nguyen X, Quignodon L, Flamant F,
Journal : Dev Biol
2011

Thyroid hormone action in cerebellum and cerebral cortex development

Author(s) : Chatonnet F, Picou F, Fauquier T, Flamant F,
Journal : J Thyroid Res
2011

[Thyroid hormone and cerebellum development: direct and indirect effects?]

Author(s) : Chatonnet F, Fauquier T, Picou F, Guyot R, Flamant F,
Journal : Ann Endocrinol (Paris)
2011

Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levels

Author(s) : Hernandez A, Quignodon L, Martinez M, Flamant F, St Germain D,
Journal : Endocrinology
2010

Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo

Author(s) : Flamant F, Quignodon L,
Journal : Heart Fail Rev
2010

Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration

Author(s) : Beby F, Housset M, Fossat N, Le Greneur C, Flamant F, Godement P, Lamonerie T,
Journal : PLoS One
2010

Deafness in TRbeta mutants is caused by malformation of the tectorial membrane

Author(s) : Winter H, Ruttiger L, Muller M, Kuhn S, Brandt N, Zimmermann U, Hirt B, Bress A, Sausbier M, Conscience A, Flamant F, Tian Y, Zuo J, Pfister M, Ruth P, Lowenheim H, Samarut J, Engel J, Knipper M,
Journal : J Neurosci
2009

Interference of a mutant thyroid hormone receptor alpha1 with hepatic glucose metabolism

Author(s) : Vujovic M, Nordstrom K, Gauthier K, Flamant F, Visser T, Vennstrom B, Mittag J,
Journal : Endocrinology
2009

[Thyroid hormone and its receptors: have mouse genetics clarified the situation?]

Author(s) : Flamant F, Quignodon L,
Journal : J Soc Biol
2008

A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism

Author(s) : Bassett J, Williams A, Murphy E, Boyde A, Howell P, Swinhoe R, Archanco M, Flamant F, Samarut J, Costagliola S, Vassart G, Weiss R, Refetoff S, Williams G,
Journal : Mol Endocrinol
2008

Peripheral circulation of the prion infectious agent in transgenic mice expressing the ovine prion protein gene in neurons only

Author(s) : Crozet C, Lezmi S, Flamant F, Samarut J, Baron T, Bencsik A,
Journal : J Infect Dis
2007

Modeling the role of mid-wavelength cones in circadian responses to light

Author(s) : Dkhissi-Benyahya O, Gronfier C, De Vanssay W, Flamant F, Cooper H,
Journal : Neuron
2007

Thyroid hormones signaling is getting more complex: STORMs are coming

Author(s) : Flamant F, Gauthier K, Samarut J,
Journal : Mol Endocrinol
2007

A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism

Author(s) : Quignodon L, Vincent S, Winter H, Samarut J, Flamant F,
Journal : Mol Endocrinol
2007

A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum

Author(s) : Quignodon L, Grijota-Martinez C, Compe E, Guyot R, Allioli N, Laperriere D, Walker R, Meltzer P, Mader S, Samarut J, Flamant F,
Journal : J Mol Endocrinol
2007

International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors

Author(s) : Flamant F, Baxter J, Forrest D, Refetoff S, Samuels H, Scanlan T, Vennstrom B, Samarut J,
Journal : Pharmacol Rev
2006

The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification

Author(s) : Bonnafe E, Touka M, AitLounis A, Baas D, Barras E, Ucla C, Moreau A, Flamant F, Dubruille R, Couble P, Collignon J, Durand B, Reith W,
Journal : Mol Cell Biol
2004

Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone

Author(s) : Dupre S, Guissouma H, Flamant F, Seugnet I, Scanlan T, Baxter J, Samarut J, Demeneix B, Becker N,
Journal : Endocrinology
2004

Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life

Author(s) : Mai W, Janier M, Allioli N, Quignodon L, Chuzel T, Flamant F, Samarut J,
Journal : Proc Natl Acad Sci U S A
2004

Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development

Author(s) : Quignodon L, Legrand C, Allioli N, Guadano-Ferraz A, Bernal J, Samarut J, Flamant F,
Journal : J Mol Endocrinol
2004

Thyroid hormone receptors: lessons from knockout and knock-in mutant mice

Author(s) : Flamant F, Samarut J,
Journal : Trends Endocrinol Metab
2003

Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum

Author(s) : Poguet A, Legrand C, Feng X, Yen P, Meltzer P, Samarut J, Flamant F,
Journal : Dev Biol
2003

Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice

Author(s) : Yen P, Feng X, Flamant F, Chen Y, Walker R, Weiss R, Chassande O, Samarut J, Refetoff S, Meltzer P,
Journal : EMBO Rep
2003

Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptors

Author(s) : Baas D, Legrand C, Samarut J, Flamant F,
Journal : Proc Natl Acad Sci U S A
2002

Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene

Author(s) : Flamant F, Poguet A, Plateroti M, Chassande O, Gauthier K, Streichenberger N, Mansouri A, Samarut J,
Journal : Mol Endocrinol
2002

Null mutant mice for thyroid hormone receptors

Author(s) : Gauthier K, Aubert D, Chassande O, Flamant F, Samarut J,
Journal : Methods Mol Biol
2002

Florid plaques in ovine PrP transgenic mice infected with an experimental ovine BSE

Author(s) : Crozet C, Bencsik A, Flamant F, Lezmi S, Samarut J, Baron T,
Journal : EMBO Rep
2001

Efficient transmission of two different sheep scrapie isolates in transgenic mice expressing the ovine PrP gene

Author(s) : Crozet C, Flamant F, Bencsik A, Aubert D, Samarut J, Baron T,
Journal : J Virol
2001

A novel growth-factor-dependent myeloid cell line derived from mouse bone marrow cells contains progenitors endowed with high proliferative potential

Author(s) : Revol V, Tsuboi I, Flamant F, Samarut J, Blanchet J, Mouchiroud G,
Journal : Exp Hematol
1999

Involvement of thyroid hormone and its alpha receptor in avian neurulation

Author(s) : Flamant F, Samarut J,
Journal : Dev Biol
1998

Identification of transcripts initiated from an internal promoter in the c-erbA alpha locus that encode inhibitors of retinoic acid receptor-alpha and triiodothyronine receptor activities

Author(s) : Chassande O, Fraichard A, Gauthier K, Flamant F, Legrand C, Savatier P, Laudet V, Samarut J,
Journal : Mol Endocrinol
1997

Vectors derived from avian leukosis and sarcoma viruses

Author(s) : Flamant F, Cosset F, Samarut J,
Journal : J Mol Med (Berl)
1995

Virofection: a one-step procedure for using replication-defective retrovirus vectors

Author(s) : Flamant F, Samarut J,
Journal : Virology
1995

Replication-competent and -defective retrovirus vectors for oncogenic studies

Author(s) : Samarut J, Flamant F, Heard J,
Journal : Methods Enzymol
1995

Virofection: a new procedure to achieve stable expression of genes transferred into early embryos

Author(s) : Flamant F, Demeneix B, Benoist C, Markossian-Belin S, Samarut J,
Journal : Int J Dev Biol
1994

Importance of 3' non-coding sequences for efficient retrovirus-mediated gene transfer in avian cells revealed by self-inactivating vectors

Author(s) : Flamant F, Aubert D, Legrand C, Cosset F, Samarut J,
Journal : J Gen Virol
1993