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External seminar: Lucie Etienne
| When |
Dec 18, 2025
from 12:15 to 01:15 |
|---|---|
| Contact Name | Lucie Bernard |
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External seminar: Lucie Etienne (CIRI, Lyon)
"Functional evolution of the cell-autonomous antiviral immunity across scales”
Abstract:
One of the first lines of defense against pathogens is the cell-autonomous innate immunity. It enables sensing of viral infections by any cell, as well as activation of a wide diversity of antiviral effector proteins. Some of the major innate immune factors, defined as “ancestral immunity”, are present throughout the tree of life and are highly conserved from prokaryotes to eukaryotes. Yet, there has been constant evolutionary arms-races between viruses and hosts that have led to their extreme diversification. Combining evolutionary biology, structural similarity, molecular virology and immunology at different scales has enabled us to discover and characterize some of these key antiviral immune defenses. It also enables us to better understand how diverse viruses may have driven host adaptations, and how these may impact modern host immunity and susceptibility/resistance to viral infections, particularly in mammalian hosts.
Host: Lucie Bernard
Thusday, December 18th
Salle des thèses