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Short Bio Team Leader

Group leader: Ontogenesis and molecular interactions

Samir MERABET

Background

  • PhD, University Aix-Marseille II, France 2002
  • Post-doc, Biozentrum, Basel, Suisse
  • CNRS position, France 2005
  • Group leader at the IGFL, Lyon, France since 2012

Main achievements

  • Deciphering the interaction networks underlying Hox protein function during Drosophila development and in cancer cell contexts
  • Understanding the role of short protein motifs during development and evolution
  • Assessing the importance of nuclear matrix proteins in shaping Hox function

Selected recent publications

  • Baeza, Viala, Heim, Dard, Hudry, Duffraisse, Rogulja-Ortmann, Brun and Merabet. (2015) Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo. eLife  Apr 14;4.
  • Hudry , Thomas-Chollier, Volovik, Duffraisse, Dard, Frank, Technau and Merabet. (2014) Molecular insights into the origin of the Hox-TALE patterning system. eLife  Mar 18 ;3.
  • Hudry, Remacle, Delfini, Rezsohazy, Graba and Merabet. (2012) Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors. PLoS Biology, June, Vol10.
  • Merabet* et al. (2011) PLoS Genetics, October; 7(10).
  • Hudry, Viala, Graba and Merabet. (2011) Visualisation of protein interactions in living Drosophila embryos by the bimolecular fluorescence complementation assay. BMC Biology. Jan 28;9(1):5.