Research and review articles





  • Samir Merabet and Brigitte Galliot. 2015. The TALE face of Hox proteins in animal evolution. Frontiers in Genetics 6:267.
  • Baeza, M., S. Viala, M. Heim, A. Dard, B. Hudry, M. Duffraisse, A. Rogulja-Ortmann, C. Brun, and S. Merabet. 2015. Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo. eLife 4.
  • Merabet, S., and I. Lohmann. 2015. Toward a New Twist in Hox and TALE DNA-Binding Specificity. Dev Cell 32:259-261.



  • Duffraisse, M., B. Hudry, and S. Merabet. 2014. Bimolecular Fluorescence Complementation (BiFC) in Live Drosophila Embryos. Methods Mol Biol 1196:307-318.
  • Boube, M., B. Hudry, C. Immarigeon, Y. Carrier, S. Bernat-Fabre, S. Merabet, Y. Graba, H. M. Bourbon, and D. L. Cribbs. 2014. Drosophila melanogaster Hox Transcription Factors Access the RNA Polymerase II Machinery through Direct Homeodomain Binding to a Conserved Motif of Mediator Subunit Med19. PLoS Genet 10:e1004303.
  • Hudry, B., M. Thomas-Chollier, Y. Volovik, M. Duffraisse, A. Dard, F. Dale, U. Technau, and S. Merabet. 2014. Molecular insights into the origin of the Hox-TALE patterning System. eLife 3:e01939.
  • Merabet, S., and A. Dard. 2014. Tracking context-specific transcription factors regulating hox activity. Dev Dyn 243(1):16-23



  • Sambrani, N., B. Hudry, C. Maurel-Zaffran, A. Zouaz, R. Mishra, S. Merabet, and Y. Graba. 2013. Distinct molecular strategies for Hox-mediated limb suppression in Drosophila: from cooperativity to dispensability/antagonism in TALE partnership. PLoS Genet 9:e1003307.
  • Rivas, M. L., J. M. Espinosa-Vazquez, N. Sambrani, S. Greig, S. Merabet, Y. Graba, and J. C. Hombria. 2013. Antagonism versus cooperativity with TALE cofactors at the base of the functional diversification of Hox protein function. PLoS Genet 9:e1003252.
  • Merabet, S., and B. Hudry. 2013. Hox transcriptional specificity despite a single class of cofactors: are flexible interaction modes the key? Plasticity in Hox/PBC interaction modes as a common molecular strategy for shaping Hox transcriptional activities. Bioessays 35:88-92.



  • Hudry, B., S. Remacle, M.C. Delfini, R. Rezsohazy, Y. Graba, and S. Merabet. 2012. "Hox proteins display a common and ancestral ability to diversify their interaction mode with the PBC class cofactors." PLoS Biol 10 (6): e1001351.



  • Saadaoui, M., S. Merabet, I. Litim-Mecheri, E. Arbeille, N. Sambrani, W. Damen, C. Brena, J. Pradel, and Y. Graba. 2011. "Selection of distinct Hox-Extradenticle interaction modes fine-tunes Hox protein activity." Proc Natl Acad Sci U S A 108 (6): 2276-2281.
  • Merabet, S., I. Litim-Mecheri, D. Karlsson, R. Dixit, M. Saadaoui, B. Monier, C. Brun, S. Thor, K. Vijayraghavan, L. Perrin, J. Pradel, and Y. Graba. 2011. "Insights into Hox protein function from a large scale combinatorial analysis of protein domains." PLoS Genet 7 (10): e1002302.
  • Hudry, B., S. Viala, Y. Graba, and S. Merabet. 2011. "Visualization of protein interactions in living Drosophila embryos by the bimolecular fluorescence complementation assay." BMC Biol 9: 5
  • Merabet, S., and B. Hudry. 2011. "On the border of the homeotic function: re-evaluating the controversial role of cofactor-recruiting motifs: the role of cofactor-recruiting motifs in conferring Hox evolutionary flexibility may critically depend on the protein environment." Bioessays 33 (7): 499-507.
  • Merabet, S., B. Hudry, M. Saadaoui, and Y. Graba. 2009. "Classification of sequence signatures: a guide to Hox protein function." Bioessays 31 (5): 500-511.
  • Merabet, S., M. Saadaoui, N. Sambrani, B. Hudry, J. Pradel, M. Affolter, and Y. Graba. 2007. "A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax." Proc Natl Acad Sci U S A 104 (43): 16946-16951.



  • Merabet, S., J.C. Hombria, N. Hu, J. Pradel, and Y. Graba. 2005. "Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis." Development 132 (13): 3093-3102.
  • Merabet, S., A. Ebner, and M. Affolter. 2005. "The Drosophila Extradenticle and Homothorax selector proteins control branchless/FGF expression in mesodermal bridge-cells." EMBO Rep 6 (8): 762-768.
  • Ebner, A., C. Cabernard, M. Affolter, and S. Merabet. 2005. "Recognition of distinct target sites by a unique Labial/Extradenticle/Homothorax complex." Development 132 (7): 1591-1600.
  • Merabet, S., J. Pradel, and Y. Graba. 2005. "Getting a molecular grasp on Hox contextual activity." Trends Genet 21 (9): 477-480.
  • Merabet, S., Z. Kambris, M. Capovilla, H. Berenger, J. Pradel, and Y. Graba. 2003. "The hexapeptide and linker regions of the AbdA Hox protein regulate its activating and repressive functions." Dev Cell 4 (5): 761-768.
  • Grienenberger, A., S. Merabet, J. Manak, I. Iltis, A. Fabre, H. Berenger, M.P. Scott, J. Pradel, and Y. Graba. 2003. "Tgfbeta signaling acts on a Hox response element to confer specificity and diversity to Hox protein function." Development 130 (22): 5445-5455.
  • Merabet, S., F. Catala, J. Pradel, and Y. Graba. 2002. "A green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryo." Genetics 162 (1): 189-202.
  • Merabet, S., A. Grienenberger, J. Pradel, and Y. Graba. 2001. "Modes d'action des protéines Hox: des interrogations nouvelles." Médecine/Sciences 7 (17): 781-786.
  • Chauvet, S., S. Merabet, D. Bilder, M.P. Scott, J. Pradel, and Y. Graba. 2000. "Distinct hox protein sequences determine specificity in different tissues." Proc Natl Acad Sci U S A 97 (8): 4064-4069.


Book Chapter

  • Marilyne Duffraisse, Bruno Hudry and Samir Merabet. Bimolecular Fluorescence Complementation (BiFC) in live Drosophila embryos. From the book "Hox genes: Methods and Protocoles", Humana Press (in press).
  • Merabet, S., N. Sambrani, J. Pradel, and Y. Graba. 2010. "Regulation of Hox activity: Insights from protein motifs."In Hox genes’ studies from the 20th to the 21st century. Edited by LandesBioscience.