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Bacterial adaptation to the host's diet, rather than to the host itself, may be the foremost step in determining the evolutionary course of a facultative animal-microbe symbiosis. Latest work from the Leulier lab.
A study of the evolution of the steroid hormone and hormone receptor couple by the team of Vincent Laudet at the Institute of Functional Genomics of Lyon (IGFL, ENS de Lyon/CNRS/Université Claude Bernard Lyon 1), associated to the team of Guillaume Lecointre at the Natural History Museum of Paris (UMR 7205 ISYEB) and other french teams , reveals a strong link between nutrition and reproduction.
Optimum growth via IGF-1 (Insulin-like growth factor 1) is ensure by intestinal microbiota, even in undernutrion. This has been demonstrated by F.Leulier's team and colleagues and published in Science.
Here is the publication in Cell Host and Microbe made by team of F. Leulier.
Team of S. Merabet has shown that specificity of interaction between Hox proteins and trancription factors relies on conserved short linear motifs. Results are published in eLife.
Chargé de recherches au laboratoire de biologie moléculaire de la cellule (LBMC), Hugo Aguilaniu dirige l'équipe "Vieillissement cellulaire des organismes"
Demonstration by Vincent Laudet and colleagues using slight variations in the amount of rate-limiting enzymes important in RA pathway
Interview spéciale sur le site de l'ENS de Lyon
Interview spéciale sur le site de l'ENS de Lyon
Physiological effects of Bisphenol A (BPA) are studied at the IGFL. This chemical compound, widely used, induces malformations of the inner ear of zebrafich and has effects on the reproductive system...more here (in french).